| ■ Possible Parkinson's trigger identified | 2008.01.09 |
| LONDON (Reuters) - A glitch in the way cells clear damaged proteins could be the trigger for the symptoms of Parkinson's disease, researchers said in a finding that could lead to new treatments for the incurable condition. The U.S. team focused on a process called autophagy in which cells digest and recycle damaged molecules, including proteins, that develop as cells grow older. This system essentially renews cells to keep them functioning properly. This mechanism is also important for nerve cells in the brain where defective proteins can kill cells and cause the debilitating symptoms of Parkinson's, such as tremors, said Ana Maria Cuervo, a cell biologist who led the study. "We have found in Parkinson's there are problems in removing abnormal proteins," said Cuervo of the Albert Einstein College of Medicine of Yeshiva University. The finding could potentially lead to drugs to treat the symptoms but not cure the disease, which affects more than a million patients in the United States alone and is marked by the death of brain cells that produce dopamine. |